Year : 2014 | Volume
: 7 | Issue : 2 | Page : 93--103
Heat shock proteins and parasitic diseases: Part 1: Helminths
Sherif M Abaza
Department of Parasitology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Heat shock proteins (HSPs) are highly conserved and immunogenic proteins that are shared among diverse groups of mammals and microbial agents. They are categorized into different families according to their molecular weight. HSPs are involved in a variety of cellular processes and essential to cell survival. They are also implicated in immune pathology and clinical manifestations of a variety of autoimmune diseases and/or metabolic disorders such as atherosclerosis, diabetes and systemic lupus erythematosus. Their role in antigen cross-presentation and cancer immunotherapy as well as initiators of immune response and targets of autoimmune attack was also reported.
The objectives of the current presentation are to summarize the functional properties of HSPs and their role in innate and acquired immune responses, to throw light on their role in pathogenesis and parasites survival, to review the literature searching for new drug discovery and vaccine candidates for parasitic diseases, and finally to present their use in diagnosis and genotyping of some parasitic diseases.
Heat shock proteins (HSPs) are highly conserved and immunogenic proteins that are shared
1. Functional Properties of HSPs
1.1. Innate immunity
1.2. Adaptive immunity:
1.3. HSPs as cancer vaccines:
1.4. HSPs as infectious disease vaccines
1.5. HSPs and apoptosis
2. Heat Shock Proteins and Helminthes
2.1. Schistosoma spp.
2.2. Echinococcus spp.
2.3. Strongyloides spp.
2.4. Trichinella spiralis
2.5. Filarial nematodes
2.6. Other helminthes
Abbreviations: APC: Antigen-presenting cell; CTL: Cytotoxic T-lymphocyte; E/S: Excretory/secretory; gp96: a member of HSP90 family; GST: Glutathione-S-transferase; HC: Hydatid cyst; HSP: Heat shock protein; IFN: Interferon; IL: Interleukin; MHC: major histocompatibility complex; NK: Natural killer; SEA: Soluble egg antigen; TLR: Toll-like receptor; TGF: Transforming growth factor; TNF: Tumor necrosis factor.
Sherif M Abaza
Department of Parasitology, Faculty of Medicine, Suez Canal University, Ismailia
|How to cite this article:|
Abaza SM. Heat shock proteins and parasitic diseases: Part 1: Helminths.Parasitol United J 2014;7:93-103
|How to cite this URL:|
Abaza SM. Heat shock proteins and parasitic diseases: Part 1: Helminths. Parasitol United J [serial online] 2014 [cited 2020 Sep 29 ];7:93-103
Available from: http://www.new.puj.eg.net/article.asp?issn=1687-7942;year=2014;volume=7;issue=2;spage=93;epage=103;aulast=Abaza;type=0